Tor Books' sumbissions pile is one possibility, another is seeking representation. On the one hand, I'm quite fond of Tor, and everything I hear of them is wonderful.
On the other, I would prefer to seek publication in a 'mainstream' venue. My story is science fiction in milieu only; it's written for the general audience.
Does anyone have a recommendation? I've heard excellent things about Writer's House, and have considered submitting there. But there is always Tor, and that fondness ...
Suggestions much appreciated.
Otherwise, I generally suggest looking for an agent first. It's generally acknowledged that publishers look more closely at agented works than the general slush. Of course, the reverse is also true, but it's possible to go back to an agent and say "Hey, I've got an offer from a publisher, would you reconsider?" whereas "Hey, I've got an agent now, would you reconsider?" meets a lukewarmm response at best.
I keep a list of good science fiction/fantasy agents:
http://www.katfeete.net/writing/agents.html
But I recommend you research each agent on your own. I'm not infalliable, and there's a lot of scammers out there.