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Author Topic: DNA question
Shigosei
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How does A-DNA differ structurally from B-DNA, and what is its purpose in the cell, if any?
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Mr.Funny
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I have no clue.

Congratulations to me on yet another completely pointless and un-informative post.

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HollowEarth
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http://en.wikipedia.org/wiki/DNA#Mechanical_properties_relevant_to_biology

It appears that there are three forms, A, B and Z. With B being normal, A appearing in dehydrated DNA or pairing of DNA and RNA, and Z appearing in methylated DNA which is identical to B but for the direction of the twist.

BTL or some else can likely give a better answer...

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rivka
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Compare A and B (image). (more here)

Detailed comparison of the three structures.

And from here:
quote:
A-DNA family - this is most common for double stranded RNA, RNA/DNA hybrids, as well as for certain DNA sequences, such as long stretches of purines.

B-DNA family - DNA exists in the "B-DNA form", most of the time inside the cells of living organisms. This is the classical "Watson-Crick" structure.

Z-DNA family - this is much more rare than the other two families, although certain sequences (such as runs of GC repeats (GCGCGC)) can form Z-DNA easily.


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Shigosei
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Well, that mostly confirms what I thought I knew, although supposedly A-DNA also occurs near sites of transcription. I'm off to give my presentation now...wish me luck!
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rivka
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How did it go?
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Shigosei
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Quite well, thanks! The professor I work for, the grad student who works most closely with me, and some of the other grad students in the lab showed up to watch me speak. The grad student even asked a question he darn well knew the answer to [Grumble] . But afterward, he told me I had given the best explanation of X-ray crystallography that he had ever seen from an undergrad/high school student (I started working in this lab as a junior in high school). The professor was also pleased with my presentation. If anyone wants to see the power point I used, I'll be happy to e-mail it to them.
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rivka
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Excellent! [Big Grin]
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Trisha the Severe Hottie
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You can send it to me [Smile] I think my address is in my profile.
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Shigosei
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Oregon State has this really cool program where undergraduate students can get grants to do research. It's funded by the Howard Hughes Medical Institute (yeah, the guy who made the Spruce Goose). Anyhow, the paper on the project I've been working on should come out in a few months--it's being reviewed now. If it's in a journal that publishes on the web, I'll try to have a link for all of you. I'm so excited about it!
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rivka
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Wow! That is so great! [Big Grin]

And to think, we can say we knew you when! [Wink]

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Shigosei
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Dad was just talking tonight about how someday at my high school they're going to point out the yearbook I worked on and say, "That yearbook was edited by Dr. Shigosei, who developed the first permanent artificial heart." He then speculated on what local places would be named after me. O_O

Trust me, when you say you knew me when, no one will know what you're talking about [Wink]

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